ABSTRACT

Objective: To determine the diagnostic accuracy of serum Cystatin C for early detection of kidney damage taking albumin Creatinine Ratio as a reference standard among people of Bahawalpur having diabetes mellitus type 2.
Study Design: A cross-sectional study.
Place and Duration of Study: The Study was conducted at the Department of Pathology in collaboration with Kidney Center, Bahawalpur Victoria Hospital, Bahawalpur, Pakistan from 27^th August 2021 to 26^th February 2022.
Methods: There was a total of 200 patients having diabetes mellitus type 2 with GFR between 60-90ml/min with an age range from 40-60 years were selected. Study participants with a history of steroid intake, hypothyroidism, chronic liver disease, AIDS, and hypertension were not included in the study. For assessment of diagnostic accuracy of Cystatin C to evaluate the renal damages in early stages, microalbuminuria was evaluated. As per the guidelines provided by the respective manufacturers, individuals exhibiting two albumin creatinine ratio (ACR) levels exceeding 30 mg/g were classified as having diabetic nephropathy (DN).
Results: The overall sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of serum Cystatin C for the early detection of kidney damage, with albumin-to-creatinine ratio used as the reference standard among individuals with type 2 diabetes mellitus, were 90.98%, 78.21%, 86.72%, 84.72%, and 86.0%, respectively.
Conclusion: The findings of this investigation indicate that serum cystatin C (CysC) exhibits a considerable level of diagnostic accuracy in the early detection of kidney damage among individuals with type 2 diabetes mellitus, utilizing the albumin-to-creatinine ratio as a reference standard.

Keywords: Creatinine, kidney diseases, Serum Cystatin, Sensitivity, Type 2 Diabetes Mellitus.

How to cite this: Sajid I, Saeed R, Goheer A, Asghar S, Saqib S, Bashir F. Diagnostic Accuracy of Serum Cystatin C for Early Detection of Kidney Damage in Patients with Type II Diabetes Mellitus:  Bahawalpur, Pakistan. Life and Science. 2024; 5(1): 41-47. doi: http://doi.org/10.37185/LnS.1.1.559