The Efficacy of Levofloxacin-Based Triple Therapy Over Standard Clarithromycin- Based Therapy for Eradication of Helicobacter Pylori

Haseeb Noor, Kazim Abbas Virk, Hyder Wajid Abbasi, Sana Tahir Virk, Sara Shahid, Muhammad Erfan


Objective: To compare a first-line Clarithromycin-based triple therapy to Levofloxacin-based triple therapy for eradicating H.Pylori.
Study Design: Comparative analysis.
Place and Duration of Study: The study was carried out at the Department of the Gastroenterology of Pakistan Institute of Medical Sciences (PIMS), Islamabad, Pakistan, from June 2021 to December 2021.
Methods: A total of 200 patients were enrolled in this comparative study, conducted in the outpatient Department of Gastroenterology. A pretested questionnaire was used to gather the required information; a group was allocated to each patient, and a response was sent to each treatment group after random sampling. The primary outcome was a negative Urea Breath test 4 weeks after completion of treatment.
Results: Out of 200 patients, 58 % (n=116) were males, and 39% (n= 84) were females. The mean age was 40.02 ± 24.4 years. Predominant presenting complaints were Retrosternal burning in 41 % (n=82), and pain and/or discomfort in the upper abdomen 34%(n=68). The response rate in the Clarithromycin based therapy group was 84% (n=84) out of 100 patients, while the response rate was 94% (n= 94) out of 100 in the Levofloxacin-based therapy group.
Conclusion: Levofloxacin-based therapy is superior to Clarithromycin-based therapy in every age group and gender.

Keywords: Clarithromycin-, Helicobacter Pylori, Levofloxacin, Peptic Ulcer.

How to cite this: Noor H, Virk KA, Abbasi HW, Virk ST, Shahid S, Erfan M. The Efficacy of Levofloxacin Based Triple Therapy Over Standard Clarithromycin Based Therapy for Eradication of Helicobacter Pylori. Life and Science. 2024; 5(1): 61-68. doi:

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