Comparison of Efficacy of Ciprofloxacin and Co-Trimoxazole in Escherichia Coli Urinary Tract Infection

Muhammad Ayaz, Sayed Ali Zeeshan Kausar, Muhammad Alamgir, Shafiq Muhammad, Fayaz Muhammad Khan, Sami Ullah


Objective: To compare the efficacy of ciprofloxacin and co-trimoxazole in urinary tract infection due to Escherichia Coli.
Study Design: A cross- sectional study.
Place and Duration of Study: This study was conducted at the Department of Medicine, Muhammad Teaching Hospital (MTH), Peshawar, Pakistan from 1st July 2022 to 31st December 2022.
Methods: Patients were randomly and consecutively assigned to either group by using lottery method (double blind). A total of 194 patients diagnosed with urinary tract infection due to E coli were randomly divided into two groups, 97 patients in each group, using 54% efficacy of ciprofloxacin, 74% efficacy of Co-Trimoxazole, 95% confidence level, and 90% power of test, using WHO software. “Group-A’ for Ciprofloxacin 500mg BD and ‘Group-B’ for Co-Trimoxazole 960mg BD. All the recruited patients were followed up after the 48th hour of their treatment and results were recorded. The chi-Square test was applied to compare the efficacy results of both drugs where a P Value < 0.05 was considered as significant value.
Results: The mean age of group A participants were 48.4 + 11.1 years, whereas, in group B it was 48.2 + 11.5 years. There were 69.1% males and 30.9% females in group A compared to 80.4% males and 19.6% females in group B. After the 48th hour of end treatment, efficacy was 79.3% and 50.5%, in groups A and B respectively (p-value = 0.000).
Conclusion: As compared to Cotrimoxazole, Ciprofloxacin is more effective in treating E. coli-caused urinary tract infections.

 Keywords: Bacteriuria, Ciprofloxacin, Co-Trimoxazole, Cystitis, Escherichia, Pyelonephritis, Pyuria.

How to cite this: Ayaz M, Kausar SAZ, Alamgir M, Muhammad S, Khan FM, Ullah S. Comparison of Efficacy of Ciprofloxacin and Co-Trimoxazole in Escherichia Coli Urinary Tract Infection. Life and Science. 2024; 5(2): 151-159. doi:

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