Comparative Effectiveness of Levofloxacin-Based Triple Regimen and Standard Clarithromycin-Based Triple Regimen in Eradication of Helicobacter Pylori - Insights from A Peripheral Hospital-Based Study

Abstract

Objective: To compare the effectiveness of a Levofloxacin-based triple regimen with the standard
Clarithromycin-based triple regimen in eradicating gastric Helicobacter pylori (H. pylori) infection.
Study Design: Quasi-experimental study.
Place and Duration of Study: This study was conducted at the Department of Medicine, Combined Military
Hospital (CMH), Sibbi, Pakistan from January 2021 to August 2022.
Methods: A total of two hundred and sixty patients (n=260), both male and female, diagnosed with H. pylori
infection, were enrolled. Patients who had used antibiotics within the past four weeks or proton pump
inhibitors within the past two weeks were excluded to avoid interference with treatment efficacy. Participants
were randomly assigned to two groups: The Levofloxacin Group received levofloxacin, amoxicillin, and
omeprazole, while the Clarithromycin Group was treated with clarithromycin, amoxicillin, and omeprazole,
each regimen lasting 14 days. After completing the eradication therapy, all patients were assessed for H. pylori
eradication using the fecal antigen test.
Results: The median age of the participants was 30.00 years (26.00–36.00). Of the patients, 158 (60.8%) were
female and 102 (39.2%) were male. Post-treatment testing revealed that 209 patients (80.4%) tested negative,
indicating successful eradication, while 51 patients (19.6%) remained positive for fecal H. pylori antigen test. In
the Clarithromycin Group, 96 patients (73.8%) tested negative, compared to 113 patients (86.9%) in the
Levofloxacin Group, showing a statistically significant difference (P = 0.008).
Conclusion: The Levofloxacin-based triple therapy regimen proved significantly more effective in eradicating
Helicobacter pylori infection than the standard Clarithromycin-based triple therapy regimen, suggesting its
potential as a valuable first-line alternative, particularly in regions with high Clarithromycin resistance.

How to cite this: Ahmad I, Bano K, Shabbir K, Razzaq K, Khan RSA, Iqbal Q. Comparative Effectiveness of Levofloxacin Based Triple Regimen and Standard Clarithromycin Based Triple Regimen in Eradication of Helicobacter Pylori - Insights from A Peripheral Hospital- Based Study. Life and Science. 2025; 6(2): 236-241. doi: http://doi.org/10.37185/LnS.1.1.341