Evaluation of Analgesic and Anesthetic Efficacy of Magnesium Sulphate in Regional Blocks: Quasi-Experimental Study

Abstract

Objective: To evaluate the anesthetic and analgesic efficacy of magnesium sulphate as an adjunct to local
anesthesia in Regional Blocks.
Study Design: A quasi-experimental study.
Place and Duration of Study: This study was conducted at the main operating theatre (OT), Combined Military
Hospital (CMH), Lahore, Pakistan from 3^rd November 2022 to 5^th September 2023.
Methods: A total of 70 patients (35 in each group), aged 18-45 years of either gender, American Society of
Anesthesiology Status I or II, undergoing ophthalmological surgeries under regional blocks were enrolled in the
study. Patients were divided into two groups: Group A - Magnesium Sulphate (N = 35) and Group B - Placebo (N =35). The peribulbar block was performed with 0.5% bupivacaine and 2 % lignocaine without adrenaline in a 10
ml syringe in equivalent proportions. In this compound of local anaesthetic, 1ml of 0.9% normal saline was
added to Group B members as a placebo treatment, while in Group A, 50 mg magnesium sulphate was added.
Lid and globe akinesia were evaluated at 1, 5, and 15 minutes, and the duration of lid and globe akinesia was
recorded. The analgesia requirement at the first and third hours was also recorded as per the visual analogue
score.
Results: Mean age of participants was 39.1 ± 5.2 years. Duration of Lid Akinesia in A and B was 115 ±7.9 minutes
and 135 ± 5.9 minutes, respectively; whereas, duration of Globe Akinesia in A and B was 180.5±7.9 minutes and
225 ± 6.5 minutes, respectively. Visual Analogue Score at 1st hour in A was 1.4 ± 0.50 and B 2.5 ± 0.50 (P<.001). At the 3^rd hour, results were 3.4 ± 1.1 and 4.5 ± 1.1 in groups A and B, respectively (^P<.001). Onset of Lid Akinesia at 1 minute in A was among 18 (51.4%) patients, whereas in B, in 3 (8.6%) (P<.001).
Conclusion: Magnesium sulphate as an adjunct to local anesthetic in regional blocks can promote earlier
inception and prolonged duration with pronounced analgesic prospects.

How to cite this: Ameer K, Ali M, Abbas MA, Kashif S, Sharif MH. Evaluation of Analgesic and Anesthetic Efficacy of Magnesium Sulphate in Regional Blocks: Quasi-Experimental Study. Life and Science. 2025; 6(2): 368-374. doi: http://doi.org/10.37185/LnS.1.1.557