Mean Platelet Volume as a Non-Invasive Marker of Liver Fibrosis in Patients with Chronic Hepatitis B: A Multicenter Study from Rawalpindi and Quetta

Abstract

Objective: To determine the mean platelet volume as a noninvasive marker of liver fibrosis in patients with
chronic hepatitis B.
Study Design: Prospective observational study.
Place and Duration of Study: This study was conducted at the Department of Gastroenterology, Combined
Military Hospital (CMH), Quetta and Pak Emirates Military Hospital (PEMH), Rawalpindi, Pakistan from August
2023 to April 2024.
Methods: A total of 132 hepatitis B patients reported to the Department of Gastroenterology were included in
the study. Convenience sampling was performed. The platelet count, Mean platelet volume, and haemoglobin
level were assessed. After a Transient Elastography (Fibroscan), fibrosis and chronicity indices were compared
to the patient haematological parameter, Mean Platelet Volume, and the accuracy and consistency of
haematological values in predicting hepatic fibrosis were investigated. Version 26.0 of the Statistical Package
for the Social Sciences was used for data entry and analysis. An independent t-test was applied between
groups.
Results: Among the total of 132 patients, 86 were male and 46 were female. Subjects were separated into two
cohorts, each consisting of 66 patients matched in age and gender. Group A with fibrosis grades F0, F1, and F2
and group B with F3 and F4. The mean platelet volume was determined in each group. Group A had a Mean
Platelet Volume (10.456 + 0.922 femtolitre). Group B had a Mean Platelet Volume of (12.745+ 1.049 femtolitre).
There were statistically significant variations in Mean Platelet Volume across the groups, as shown by an
independent sample t-test (P<0.01).
Conclusion: MPV is a noninvasive indicator of liver fibrosis in chronic hepatitis B patients. We suggest that MPV
could be helpful in evaluating fibrosis in these patients. Because a stand-alone test is nonspecific concerning
other illnesses, it should not be considered for this purpose.

How to cite this: Ahmad MI, Ahmad I, Khan FR, Nasir JA, Hannan A, Nisa Q. Mean Platelet Volume as a Non-Invasive Marker of Liver Fibrosis in Patients with Chronic Hepatitis B: A Multicenter Study from Rawalpindi and Quetta. Life and Science. 2025; 6(2): 196-201. doi: http://doi.org/10.37185/LnS.1.1.782