Effect of Vitamin D Supplementation on Lipid Profile Among Patients with Metabolic Syndrome: Randomized Controlled Trial in Tertiary Care Setting, Rawalpindi

Abstract

Objective: To evaluate the effect of vitamin D supplementation on lipid parameters in patients with metabolic
syndrome
Study Design: Randomized controlled trial.
Place and Duration of Study: This study was conducted at the Department of Medicine, Pak Emirates Military Hospital (PEMH), Rawalpindi, Pakistan, from April 2024 to July 2024.
Methods: Adult patients satisfying the National Cholesterol Education Program Adult Treatment Panel III criteria for metabolic syndrome were included. Exclusion criteria included current use of statins, use of vitamin D supplements during the last 6 months, hypothyroidism, pregnancy, chronic kidney disease stages 3- 5, nephrotic syndrome, and cholestasis. Patients in the intervention arm were given Vitamin D3 in two oral doses of 200000 IU each, taken at weeks 0 and 4, in addition to usual medications. Patients in the control arm received only usual medicines. Serum total cholesterol, triglycerides, high-density lipoproteins, and low-density
lipoproteins were measured at baseline and after eight weeks.
Results: There were 78 patients aged 49.41± 11.84 years. Median high-density lipoprotein levels increased by 0.09 mg/dL in the intervention group, as compared to a decrease of 0.02 mg/dL in the control group (P=0.03). This change was significant in patients with sufficient vitamin D levels as baseline, but not amongst those with vitamin D deficiency. Administration of vitamin D was not associated with a substantial change in total cholesterol, triglycerides, or low-density lipoproteins.
Conclusion: In adults with metabolic syndrome, administration of vitamin D supplements is associated with a beneficial effect on serum high-density lipoproteins.

How to cite this: Hussain A, Arshad AR, Begum M. Effect of Vitamin D Supplementation on Lipid Profile Among Patients with Metabolic
Syndrome: Randomized Controlled Trial in Tertiary Care Setting, Rawalpindi. Life and Science. 2026; 7(1): 87-93. doi:
http://doi.org/10.37185/LnS.1.1.849