ABSTRACT

Objective: To find the association of lipid profile with cholelithiasis.
Study Design: A case-control study.
Place and Duration of Study: The study was carried out at the Department of Pathology, Pakistan Institute of Medical Sciences (PIMS) Hospital, Islamabad from April 2022 to April 2023.
Methods: This study recruited 100 known cases of cholelithiasis aged 20 to 70 years, having gall stones diagnosed through ultrasonography presenting to the hospital. These cases were compared with 100 controls who had past records of their laboratory reports from this hospital, in this case-control study. The past data of their laboratory reports of lipid profile including serum concentrations of Total Cholesterol, Triglycerides, HDL cholesterol, and LDL cholesterol levels and other tests such as fasting blood glucose (FBG), total bilirubin (T-bil), alanine transaminase (ALT), serum creatinine (Cr), uric acid (UA), and urea nitrogen (UN) were compared.
Results: The mean ages of the cases and controls were 51.71±13.48 and 42.00±13.14 years, respectively. There was no variance in the BMI of both groups. The logistic regression analysis presented data where significant differences within lipid profile values of cases and controls could be seen having higher values reported in cases than controls. The multivariant analysis of the lipid profile analyzed values presented a significant variance in the odds ratio of high-density lipoprotein, HDL cholesterol levels, and Triglycerides of the cases and controls.
Conclusion: Low levels of high-density lipoprotein (HDL) cholesterol and high levels of Triglycerides are associated with a high risk of gall bladder stone formation.

Keywords: Cholelithiasis, High Density Lipoprotein Cholesterol (HDL), Triglycerides.

How to cite this: Siddiqa A, Khan S, Rafique M, Hanif F, Anwer MS, Khattak A. The Association of Dyslipidemias with Cholelithiasis: A Case-Control Study Conducted at Pakistan Institute of Medical Sciences (PIMS), Islamabad. Life and Science. 2024; 5(2): 166-171. doi: http://doi.org/10.37185/LnS.1.1.428